WebArrowhead, as in (A). (E-G) Proliferation assays of cells from (D), showing growth of cells expressing shNSD2 compared to control shRNA in (E), shSETD2 compared to control shRNA in (F), and H3.3K36M compared to H3.3WT control in (G). Cells were maintained in selection media and counted every two days for the duration of the assay. WebXenografts formed by shNSD2 cells were smaller in appearance compared with those formed by shNC cells (Fig.2E). After tumors became visible to naked eyes, tumor volumes were calculated every 4 days and a tumor growth curve is drawn, which indicated that tumors in the shNSD2 group grew slowly compared with the shNC group (Fig.2F).

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Web6 Sep 2024 · Nuclear receptor binding SET domain protein 2 (NSD2), a histone methyltransferase which catalyzes the di-methylation of histone H3 at lysine 36, has been proved a critical molecule in... Web16 Feb 2024 · Knockdown of EZH2 or NSD2 was accomplished using specific lentivirus shRNA vectors. The target sequences of shRNA were as follows: shEZH2 (5′-GCTAGGTTAATTGGGACCAAA-3′) , shNSD2 (5′-GCACGCTACAACACCAAGTTT-3′) , and shNC (5′-TTCTCCGAACGTGTCAGGT-3′). The shRNA templates targeting EZH2 and shNC were … sunova koers

Long non-coding RNAs MACC1-AS1 and FOXD2-AS1 mediate …

Web6 Sep 2024 · Nuclear receptor binding SET domain protein 2 (NSD2), a histone methyltransferase which catalyzes the di-methylation of histone H3 at lysine 36, has been … WebMonensin significantly inhibited the proliferation of myeloma cell lines examined with IC50 of about 1 micro M. Cell cycle analysis indicated that monensin induced a G1 and/or a G2-M phase arrest in these cell lines. To address the mechanism of the antiproliferative effect of monensin, we examined the effect of this drug on cell cycle-related ... WebXenografts formed by shNSD2 cells were smaller in appearance compared with those formed by shNC cells (Fig.2E). After tumors became visible to naked eyes, tumor volumes … sunova nz