WebFeb 13, 2008 · High-dose thiotepa, a polyfunctional alkylating agent used in the treatment of solid tumors in children and adults, has been reported to cause a variety of reactions in the skin, including erythema, blistering, and hyperpigmentation. Reports vary in descriptions of the prevalence, severity, and nature of cutaneous reactions to thiotepa. To further … WebFeb 13, 2024 · Serious neurological adverse events (NAE) have occurred during treatment with high-dose thiotepa regimens of children with high-risk solid tumours. The objective was to assess the incidence of NAE related to high-dose thiotepa and to identify potential contributing factors that could exacerbate the occurrence of this neurotoxicity. From May …
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WebPrevention. Horn et al. r found elevated levels of thiotepa in gauze containing sweat and occluded and nonoccluded skin, suggesting that thiotepa is excreted onto the skin by … WebThiotepa (TEPADINA ®) is used to treat some blood cancers and several other types of cancer. It is given before a stem cell transplant or bone marrow transplant. It is best to read this information with our general information about chemotherapy and the type of cancer you have. Your doctor will talk to you about this treatment and its possible ... stimpson eves
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WebThiotepa (Tepadina) Thiotepa is a chemotherapy drug. It is mainly used to prepare people for a bone marrow transplant. How does thiotepa work? Thiotepa is a type of drug called an alkylating agent. It works by sticking to 1 of the cancer cell's DNA strands. Then the cell can't divide into 2 new cells. WebThiotepa can sometimes cause some changes to your child’s liver function. This should return to normal when the treatment is finished. ... Your child’s body will get rid of the … WebFeb 17, 2024 · Boxed Warning. Myelosuppression: Thiotepa may cause severe marrow suppression, and high doses may cause marrow ablation with resulting infection or bleeding. Monitor hematologic laboratory parameters. Hematopoietic progenitor (stem) cell transplantation is required to prevent potentially fatal complications of the prolonged … stimpson law tecumseh mi